Statistical issues in prevention and therapeutic trials of Alzheimerdisease
R. Brookmeyer
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 27- 30
|
| Opplysninger | Relatively little attention has been given to the proper design andstatistical analysis of prevention and therapeutic trials ofAlzheimer disease (AD). A number of important methodological issuesarise in studies of AD that do not typically arise in studies ofother chronic diseases. These issues include: the definition of theprimary study endpoint that is simple to measure and easy tointerpret; proper design of trials that take into account that thepatient population is very old; and the proper statistical analysisthat addresses the high drop out rate and the multiple ways ofmeasuring disease severity. Addressing these issues will speed theprogress of the evaluation of promising compounds to prevent andtreat AD.
|
| Emner |
