Age vs. aging in the pathogenesis of senile dementia of the Alzheimertype: Electrophysiological evidence
A.L. Politoff
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | Side 18- 25
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| Opplysninger | Is senile dementia of the Alzheimer type (SDAT) the end result ofaging of the brain (serial or aging-related model) or the result ofsome other mechanism that runs in parallel to normal aging (parallelor age-related model)? This question can be answered by comparingvariables that measure biological aging (aging-dependent variables,ADVs) of normal individuals and of SDAT patients. If the serial modelapplies, the values of the ADVs of SDAT patients should be at theupper end of the normal ADV curves. In control individuals the powerof the alpha band in the 2-Hz flash-stimulated EEG at the posteriorhead regions increased with age, while the power of the delta band inthe resting EEG at the anterior head regions decreased. In SDATpatients the ADVs were significantly different from normal andopposite to the trend of normal aging, supporting the parallel modeland suggesting that the pathogenesis of SDAT is different from normalaging.
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| Emner |
