Low body weight in Alzheimer's disease is associated with mesialtemporal cortex atrophy
M. Grundman
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 1585- 1591
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| Opplysninger | There are reports of weight loss and low body mass index (BMI) inpatients with AD. The mesial temporal cortex (MTC)is involved infeeding behavior and memory and is preferentially involved in AD. Westudied 74 subjects, including 58 AD patients and 16 controlsubjects, to determine whether BMI is associated with atrophy of theMTC or-other brain regions. We used MRI morphometric analysis toprovide measures of regional brain atrophy. AD patients hadsignificant brain atrophy in all measured brain regions, except thewhite matter, compared with normal control subjects. The MTC was theonly brain region significantly associated with BMI in AD patients (r= 0.39, p = 0.003). Multiple-regression analysis indicated thataddition of brain regions other than the MTC to the model did notsignificantly add to the prediction of BMI. We conclude that low BMIcorrelates best and specifically with MTC atrophy. This findingsupports a connection between limbic system damage and low bodyweight in AD.
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| Emner |
