New approach to drug therapy in Alzheimer's dementia
A. Maelicke
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 53- 59
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| Opplysninger | Most current drug therapeutic approaches to Alzheimer's dementia areaimed either at elevation of the transient levels of acetylcholine inthe brain or at direct enhancement of nicotinic receptor activationby the application of cholinesterase inhibitors or nicotinicagonists, respectively. One problem of the latter approach is agonist-induced desensitization of nicotinic receptors. An alternativeoption, which could circumvent this problem, involves a novel classof nicotinic ligands, which potentiate the response of nicotinicreceptors to acetylcholine by acting from an allosteric site. Themechanism of action and the structure-function relationship of thesepotential drugs is discussed.
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| Emner |
