White matter disease and dementia


S.M. Rao
Bok Engelsk 1996
Utgitt
1996
Omfang
Side 250- 268
Opplysninger
Dementia is a common occurrence in patients with disorders affectingcerebral hemispheric white matter. Relatively little is known,however, about the specific pattern of neurobehavioral changesassociated with abnormal white matter function. This review examinesin detail the neurobehavioral features of a common white matterdisease, multiple sclerosis (MS). The neuropsychologicalcharacteristics of MS-related dementia are compared and contrastedwith those observed in three other white matter disorders (acquiredimmune deficiency syndrome, Binswanger's disease, and closed headinjury) to determine if ''white matter dementia'' should berecognized as a unique diagnostic entity distinct from otherdementing conditions. Finally, possible mechanisms by which whitematter disease affects behavior are proposed. (C) 1996 AcademicPress, Inc.
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