Topography of brain atrophy during normal aging and Alzheimer'sdisease
K.L. Double
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 513- 521
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| Opplysninger | The present study investigated the effect of age on total andregional brain volumes and compared age-associated changes in 20healthy controls with those observed in 12 patients with Alzheimer'sdisease (AD). Weights and volumes of the whole brain and cerebrum, aswell as the fractional volumes of the frontal, temporal, and parieto-occipital cortices, medial temporal structures, deep brainstructures, and white matter were measured. Males had larger andheavier brains than females of comparable age. A small decline inbrain volume with age was found (approximately 2 mi per year), butonly within the white matter. In comparison, no further loss of whitematter occurred in AD; however, the cerebral cortex was significantlyreduced in volume, with the greatest loss from the medial temporalstructures. This loss was related to disease progression; greaterproportional loss was associated with more rapid decline in olderpatients. This study suggests that significant brain atrophy is not aconsequence of advancing age. Ln addition, it suggests a regionalspecificity of damage in AD.
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| Emner |
