Treatment of Alzheimer's disease: Future directions
G.K. Wilcock
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 128- 136
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| Opplysninger | Following the introduction of tacrine hydrochloride (Cognex(R)) inthe United States and several other countries, researchers arepursuing two broad therapeutic strategies for Alzheimer's disease(AD). The first involves identifying agents or combinations of agentswhose actions can compensate for the considerable cerebral damagethat has typically occurred by the time the diagnosis of AD is made.Such therapeutic approaches include the development of additionalcholinesterase inhibitors, agents that work on the receptors of othersystems damaged by the disease process, and anti-inflammatory andimmunomodulatory agents. The second and ultimately more promisingstrategy involves the development of approaches to retard, halt, oreven prevent disease progression. Such protective approaches, whichdepend on the development of more effective methods for predictingand diagnosing AD, include the administration of nerve growth factorand other neurotrophins and the use of pharmacologic or geneticinterventions to limit amyloid deposition and the formation ofneurofibrillary tangles.
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| Emner |
