Erythrocytic calpain-calpastatin system in Alzheimer's disease
L. Soldati
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 106- 108
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| Opplysninger | Calpains, calcium activated neutral proteases (CANP), and calpastatin(CAST), their specific inhibitor, are involved in the proteolysis ofamyloid precursor protein (APP), which is thought to be abnormal inAlzheimer's disease (AD). We studied the CANP/CAST system inerythrocytes of 14 clinically probable AD patients, II young and 14old controls. CANP and CAST activities in the control subjectssignificantly correlated with increasing age, old controls showed asignificant increase in CANP and CAST activities compared to youngcontrols. Values of CANP and CAST activities in AD patients weresimilar to those of young controls. The physiological age-relatedincrease in proteolysis seems to be lost in AD patients, and thiscould play a role in the pathogenesis of the disease. However, due tothe overlap of results between patients and controls, we could notreliably differentiate the healthy from tile disease state on thebasis of erythrocytic CANP/CAST activity.
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| Emner |
