Senile dementia of Alzheimer type and multi-infarct dementiainvestigated by transcranial Doppler sonography
H. Sattel
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 41- 46
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| Opplysninger | Dementia of the Alzheimer type, senile onset (SDAT), and multi-infarct dementia (MID) exhibit differences in cerebrovascular bloodflow velocity profiles, which were investigated by means oftranscranial Doppler sonography. The pulsatility indices (PI), asangle-independent parameters of peripheral vascular resistancemeasured in the basal cerebral arteries, were significantly increasedin MID patients with respect to SDAT cases. In an analysis of thecorrelations between several variables and the magnitude of PI, wefound strong inverse correlations of the CAMCOG score, and strongdirect correlations of the blood pressure and the duration ofillness, with the PI of all basal cerebral arteries only in MIDpatients. In SDAT patients, we found a direct correlation between theHachinski ischemia score and the PI of all basal cerebral arteries.All 3 ischemia scores (Hachinski, Rosen, Loeb and Gandolfo) weresignificantly correlated with the PI of the middle cerebral andbasilar arteries. By analyzing the correlations of the single itemsof the 3 different ischemia scores with the PI values obtained, weonly found a clearcut correlation with the item focal neurologicalsigns. Thus, our findings stress the relative importance of aconcomitant cerebrovascular factor in the development of dementia inold age, even in patients with probable SDAT. A raise of the PI inthe basal cerebral arteries allows early suspicion of acerebrovascular factor even in only slight dementia so that possiblerisk factors for further aggravation of this type of vasculardementia might be detected and treated early in the course ofdisease.
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| Emner |
