Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the alzh - detaljert visning

Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the alzheimer type

Y. Wakutani
Bok Engelsk


Utgitt	Y Wakutani Tottori Univ Sch Med Inst Neurol
Opplysninger	The heat shock protein 70 (HSP70) gene is located in chromosome 14, it is now considered as a molecular 'chaperone' and a cell-protective agent. It may be closely related to the pathogenesis of dementia of the Alzheimer type (DAT). To examine the relationship between HSP70 and T, HSP70 mRNA expression levels in mononuclear blood cells (MBCs) from patients with DAT were measured by Northern blotting. We found no significant correlation between HSP70 mRNA levels and aging. We found that HSP70 mRNA levels in MBCs from patients with DAT were significantly lower than those from patients with vascular dementia and nondemented controls. These findings suggest that the lower levels of constitutive HSP70 mRNA in DAT play an important role in developing DAT and that the measurement of HSP70 mRNA may be useful for the diagnosis of DAT.
Emner	Dementia of the Alzheimer Type Disease EXPRESSION GENE Vis mer... HSP70 MESSENGER-RNA Mutation NEURONS Northern blotting AMYLOID PRECURSOR PROTEIN STATE Stress mononuclear blood cells
ISSN	1013-7424