Familial risks for alzheimer disease from a population-based series

C. Hirst
Bok Engelsk


Utgitt	AD Sadovnick Univ British Columbia Dept Med Ge
Opplysninger	Kaplan-Meier risks estimates are calculated and compared for two consecutive series (N-1 = 840, N-2 = 819) of first- degree relatives of Alzheimer disease (AD) patients diagnosed as either ''probable'' or ''autopsy-confirmed'' AD. The consistency of results increases confidence in estimates and suggests consistent case ascertainment over 8 years. Lifetime risk estimates to age 88 for the combined sample (23.4% +/- 3.0%) do not approach the 50% risk compatible with an autosomal dominant model of transmission. These results support our previous finding and suggest that an autosomal dominant gene(s) is not responsible for all cases of AD. (C) 1994 Wiley-Liss,Inc.
Emner	1st-degree relatives ADRDA work group Age factors CRITERIA Vis mer... Clinical Diagnosis DISORDERS Dementia Mutation ONSET cued recall lifetime risk estimates risk counseling
ISSN	0741-0395

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