Risk factors for late-onset Alzheimer's disease: A population-based, case-control study
Laura et al. Fratiglioni
Bok Engelsk 1993
| Utgitt | 1993
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| Omfang | 9 s.
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| Utgave | Kopi
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| Opplysninger | Our current knowledge of risk factors for Alzheimer's disease is limited and primarily addresses early-onset disease. This study aimed to determine the risk factors for late-onset Alzheimer's disease using a case-control approach. Ninety-eight cases and 216 controls were gathered from an ongoing population survey on aging and dementia in Stockholm ( the Kungsholmen Project). We found a high relative risk (3.2;95% confidence interval, 1.4-13.8) and manual work (relative risk for men of 5.3; 95% confidence interval, 1.1-25.5) emerged as positively assosiated. No clear association was found with a family history of Parkinson disease, advanced parental age at index delivery, season of birth, ot previous head trama. In cocnclusion, our data suggest that the main risk factor for late-onset Alzheimer's disease is a family history of dementia, as has been previously reported for early-onset disease. Moreover, alcohol abuse and occupational exposure might play a specific role for this form of the disease.
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