Regulation of energy metabolism in skeletal muscle cells : involvement of the cysteine protease legumain and crosstalk with bone cells
Nimo Mukhtar Mohamud Osoble
Bok · Engelsk · 2025 · Doktoravhandlinger
Tekstet på: Engelsk, Bokmål
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| Opplysninger | Delvis opptrykk av artikler. - Thesis for the degree of Philosophiae Doctor (Ph.D.) submitted to the Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo. - Avhandling (Ph.D) - Universitetet i Oslo, 2025. - Crosstalk between bone and skeletal muscle -- Energy metabolism in the body -- Energy metabolism in skeletal muscle -- Energy metabolism in mitochondria -- Proteolytic enzymes -- Cysteine proteases -- Legumain -- Localization and activities of proteases -- Legumain deficient mice -- Aims of the present studies -- Summary of papers -- Discussion -- Methodical considerations -- Cellular in vivo models -- Primary skeletal muscle cells -- Human donor characteristics -- Human bone marrow stromal cell metabolism -- Effects of conditioned media on protease activity in cultured cells -- Legumain deficient mice : crosstalk between cells in vitro.. - Denne avhandlingen utforsker reguleringen av energimetabolisme i skjelettmuskelceller, med fokus på rollen til cysteinproteasen legumain og dens samspill med beinceller. Den undersøker de fysiologiske effektene av legumain, dens lokalisering og aktivitet i skjelettmuskelmetabolisme. Studien undersøker også samspillet mellom skjelettmuskelceller og beinceller, og gir innsikt i metabolske prosesser og deres implikasjoner for helse og sykdom.. - This dissertation explores the regulation of energy metabolism in skeletal muscle cells, focusing on the role of the cysteine protease legumain and its crosstalk with bone cells. It examines the physiological effects of legumain, its localization, and its activity in skeletal muscle metabolism. The study also investigates the interaction between skeletal muscle cells and bone cells, providing insights into the metabolic processes and their implications for health and disease.
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