| |
|---|
| Omfang
| 1 bind (varierende paginering) : figurer
|
|---|
| Opplysninger
| Delvis opptrykk av artikler. - Avhandling (Ph.D) - Universitetet i Oslo, 2025. - Publisher description: "Our gut is home to trillions of microorganisms—collectively known as the gut microbiome—that play a role in health and disease. Research suggests that changes in the microbiome may be linked to colorectal cancer (CRC) development and that it may serve as an early indicator (a biomarker) for CRC. Current CRC screening methods often lack precision when it comes to CRC detection, highlighting the need for improved screening tools. This thesis explores the gut microbiome as a source for CRC biomarkers. We demonstrate that healthy individuals, those with early signs of colorectal cancer (adenomas), and CRC patients have different microbiomes and that these changes are noticeable 10 years before diagnosis. One bacterium, Phascolarctobacterium succinatutens, was the most commonly detected bacterium in CRC patients, which was not found in healthy individuals or people with CRC. We further show that different bacterial communities, including the presence of Phascolarctobacterium succinatutens, may be associated with the development of colorectal cancer. Lastly, we highlight the importance of considering sex differences in microbiome biomarker studies, as more variation in the female microbiome, which is related to the severity of colorectal lesions, could be observed. This thesis advocates for Phascolarctobacterium succinatutens as a CRC biomarker candidate and emphasizes the importance of considering sex in microbiome biomarker studies."
|
|---|
| Emner
| |
|---|
| Sjanger
| |
|---|
| Dewey
| |
|---|
