Design of experiments : principles and applications /
L. Eriksson, E. Johansson, N. Kettaneh-Wold, C. Wikström, and S. Wold.
Bok · Engelsk · 2008
| Medvirkende | |
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| Omfang | xiii, 459 s. : ill. (huvudsakligen i färg)
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| Utgave | 3., rev. and enl. ed.
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| Opplysninger | Handbok till datorprogram. - Preface -- Introduction -- Problem formulation -- Factorial designs -- Analysis of factorial designs -- Experimental objective: screening -- Experimental objective: optimization -- Experimental objective: robustness testing -- Additional screening designs for regular regions -- Additional optimization designs for regular regions -- D-optimal design -- Mixture design -- Multilevel qualitative factors -- Onion design -- Blocking the experimental design -- The Taguchi approach to robust design -- Models of variability: distributions -- Analysis of variance, ANOVA -- PLS -- DOE in organic chemistry -- DOE in assay development -- DOE in formulation development -- DOE in PAT -- Appendices. - This is the third and extended edition of the book "Design of Experiments". It describes tools for making experiments in a way that maximizes the resulting knowledge in a minimum number of trials. The book gives a detailed introduction to the use of these tools with excellent illustrations of PC-based software as an integrated tool in design and analysis of experiments. It includes some newly developed approaches for biological and pharmaceutical R&D. Experimentation is used everywhere in business, academic research, and industrial development and troubleshooting to investigate and improve processes and products. Often this involves optimization, i.e., how to get maximum performance or results in a given process. In research, development, and production, often half of the available experimental resources are spent on solving optimization problems. How can we, for example, find the optimal conditions for a synthesis or a purification step? Which combination of our factors will give the best yield and lowest impurities, at lowest possible cost, using lowest possible use of energy and raw materials, and producing a minimum of pollution? With the rapidly increasing costs of experiments, it is essential that these questions are answered with as few experiments as possible. Design of Experiments, DOE, is used for this purpose - to ensure that the selected experiments are maximally informative.
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| Emner | |
| Dewey | |
| ISBN | 9197373044. - 9789197373043
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