The Genetics of Cancer : Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation


Gajanan V. Sherbet
Bok Engelsk 1997 · Electronic books.
Annen tittel
Utgitt
Burlington : : Elsevier Science, , 1997.
Omfang
1 online resource (361 p.)
Opplysninger
Description based upon print version of record.. - Front Cover; The Genetics of Cancer; Copyright Page; Contents; Preface; Abbreviations; Chapter 1. Introduction; Chapter 2. Clonal evolution of the metastatic phenotype; Manifestation of genetic instability; Chromosomal abnormalities in cancer; Clonal expansion of tumour cell subpopulations; Genetic instability and the generation of metastatic variants; DNA repair and repair fidelity in metastatic variants; Genetic recombination in the generation metastatic variants; Microsatellite instability in cancer progression. - Chapter 8. Cell surface glycoproteins and their receptorsIntegrin receptors and their function; Vitronectin receptors; Laminin receptors; Cadherins; Tenascin; CD44 and its isoforms; Cell adhesion molecules (CAMs) in cancer invasion; Chapter 9. Proteinases and their inhibitors in cancer invasion; Urokinase in cancer invasion and metastasis; Cathepsins in cancer invasion and progression; Matrix metalloproteinases (MMPs) in cancer; Chapter 10. Oncogenes and cancer metastasis; The ras oncogene in tumorigenesis; Erb genes as predictors of cancer progression and prognosis. - Epidermal growth factor receptors in cancer. - Regulation of mdm2 by p53mdm2 abnormalities in cancer; mdm2 and tumour progression; Transactivation of growth factor receptor genes by p53; GADD genes and their regulation by p53; Metastasis-associated 18A2/mtsl gene in cell cycle progression; Retinoblastoma susceptibility gene (rb) abnormalities in cancer; Cyclins, cell cycle progression and cyclins as proto-oncogenes; Cyclin-dependent kinase (cdk) inhibitors as tumour suppressors; Structural and functional features of group 1 cdk inhibitors; Regulation of waf1/cip1 gene expression by p53; Is the waf1/cip1 gene altered in cancer?. - Response of kip1/kip2 genes to antiproliferative signalskip1 gene expression in neoplasia; p16/ink4 putative multiple tumour suppressor gene in tumour development and progression; Heat shock proteins (HSPs) in development, differentiation and tumorigenesis; Chapter 6. Apoptosis in tumour growth and metastasis; The nature of apoptotic changes; Genetic regulation of apoptosis; Chapter 7. Angiogenesis in cancer; Induction of neovascularisation by tumours; Inhibitors of neovascularisation; Angiogenesis as a predictor of prognosis of cancer. - Telomerase function, genetic instability, cell proliferation and cancer metastasisChapter 3. Inefficiency of the metastatic process; Chapter 4 Tumour growth and metastatic potential; Chapter 5. Cell cycle regulation and pathogenesis of cancer; The regulatory role of p53 in G1-S and G2-M transition in cell cycle progression; Genomic organisation of the p53 gene; p53 abnormalities and dysfunction; Regulation of p53 function; p53, cancer progression and prognosis; Subcellular localisation of p53 protein; p53 protein as a transcription factor; Alternative splicing of the p53 gene transcript. - Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, a
Emner
Biological Science Disciplines
Biology
Cell transformation, neoplastic - Genetics
Disciplines and Occupations
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Dewey
ISBN
0126398755

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