Bioinformatics and Functional Genomics
Jonathan. Pevsner
Bok Engelsk 2005 · Electronic books.
| Utgitt | Hoboken : : Wiley, , 2005.
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| Omfang | 1 online resource (789 p.)
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| Opplysninger | Description based upon print version of record.. - BIOINFORMATICS AND FUNCTIONAL GENOMICS; Contents in Brief; Contents; Foreword; Preface; PART I ANAlYZlNG DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES; 1 Introduction; Organization of The Book; Bioinformatics: The Big Picture; A Consistent Example: Retinol-Binding Protein; Organization of The Chapters; Suggestions For Students and Teachers: Web Exercises and Find-a-Gene; Key Bioinformatics Websites; Suggested Reading; References; 2 Access to Sequence Data and Literature Information; Introduction to Biological Databases; GenBank: Database of Most Known Nucleotide and Protein Sequences. - (1) LocusLink: Centralized Resource for Information on Genes and ProteinsNCBI Reference Sequence (RefSeq): Best Representative Sequences; (2) UniGene; (3) Entrez; (4) European Bioinformatics Institute and Ensembl; (5) ExPASy; Example of How to Access Sequence Data: HIV pol; Access to Biomedical Literature; PubMed Central and Movement toward Free Journal Access; Example of PubMed Search: RBP; Box 2-2. Venn Diagrams of Boolean Operators AND, OR, and NOT for Hypothetical Search Terms 1 and 2; Perspective; Pitfalls; Web Resources; Discussion Questions; Problems; Self-Test Quiz; Suggested Reading. - Amount of Sequence DataOrganisms in GenBank; Types of Data in GenBank; Genomic DNA Databases; cDNA Databases Corresponding to Expressed Genes; Protein Databases; Expressed Sequence Tags (ESTs); ESTs and UniGene; Sequence-Tagged Sites (STSs); Genome Survey Sequences (GSSs); High-Throughput Genomic Sequence (HTGS); National Center for Biotechnology Information; Introduction to NCBI: Home Page; PubMed; Entrez; BLAST; OMIM; Books; Taxonomy; Structure; Accession Numbers: Labels to Identify Sequences; Box 2-1. Types of Accession Numbers; Five Ways to Access DNA and Protein Sequences. - Practical Usefulness of PAM Matrices in Pairwise AlignmentImportant Alternative to PAM: BLOSUM Scoring Matrices; Pairwise Alignment and Limits of Detection; Alignment Algorithms: Global and Local; Global Sequence Alignment: Algorithm of Needleman and Wunsch; Box 3-6. Genetics Computer Group; Local Sequence Alignment: Smith and Waterman Algorithm; Rapid, Heuristic Versions of Smith-Waterman: FASTA and BLAST; Basic Local Alignment Search Tool (BLAST); Significance of Pairwise Alignments: Percent Identity; Box 3-7. Dot Plots; Tests for Statistical Significance of Pairwise Alignments. - References3 Pairwise Sequence Alignment; Introduction; Protein Alignment: Often More Informative Than DNA Alignment; Definitions: Homology, Similarity, Identity; Box 3-1. Structures and One- and Three-Letter Abbreviations of Twenty Common Amino Acids; Box 3-2. Algorithms and Programs; Gaps; Pairwise Alignment, Homology, and Evolution of Life; Dayhoff Model: Accepted Point Mutations; Box 3-3. Dayhoff's Protein Superfamilies; PAM1 Matrix; PAM250 and Other PAM Matrices; Box 3-4. Genetic Code; Box 3-5. Matrix Multiplication; From a Mutation Probability Matrix to a Log-Odds Score Matrix. - Statistical Significance of Global Alignments. - Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University ""Teacher of the Year"" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explain
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| Emner | Bioinformatics
Genetics - Data processing Genomics Proteomics Vis mer... Amino Acids, Peptides, and Proteins
Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemicals and Drugs Computational Biology Disciplines and Occupations Genetic Phenomena Genetic Structures Genetic Techniques Genome Genome, Human Investigative Techniques Natural Science Disciplines Phenomena and Processes Proteins Proteome Data processing. Molecular biology. Bioinformatikk Biology Databehandling Genetikk Genomer Health & Biological Sciences genomer bioinformatikk proteomikk genetikk databehandling |
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| ISBN | 0471210048
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