The Immunoglobulins : Structure and Function


Roald. Nezlin
Bok Engelsk 1998 · Electronic books.
Annen tittel
Utgitt
Burlington : : Elsevier Science, , 1998.
Omfang
1 online resource (292 p.)
Opplysninger
Description based upon print version of record.. - Front Cover; The Immunoglobulins: Structure and Function; Copyright Page; Contents; Preface; Part I :Structural Aspects; Chapter 1. General Characteristics of Immunoglobulin Molecules; I. Immunoglobulin Classes; II. Heterogeneity of Immunoglobulins; III. Detection and Isolation of Immunoglobulins; IV. Proteolytic and Chemical Fragments of Immunoglobulins; V. Immunoglobulin Peptide Chains; VI. Additional Peptide Chains; VII. Immunoglobulin Fold (Domain); VIII. Fab Portion; IX. Fc Portion; X. Immunoglobulin Molecules; XI. Carbohydrate Components of Immunoglobulins; References. - Chapter 2. Animal and Human ImmunoglobulinsI. Low Vertebrates; II. Birds; III. Mammals; IV. Human Immunoglobulins; V. Origin of Antibody Diversity in Mice and Humans; VI. Evolutionary Aspects; References; Chapter 3. Engineering Antibody Molecules; I. Problems of Serum Immunotherapy; II. Chimeric Antibody Molecules and Humanization; III. Minimal Antibody Fragment (Fv); IV. Production of Human Monoclonal Antibodies; V. Engineering of Immunoglobulins with Novel Properties; VI. Polymerization of IgG Molecules and Their Fragments; VII. Bispecific Antibodies; References; Part II: Functional Aspects. - Chapter 4. Antigen-Combining SiteI. General Characteristics; II. Conformational Changes Linked with Antigen Binding; III. Complex of VH Domain of Camelid Heavy Chain Antibodies with Antigen; IV. Interaction of an Autoantibody (Rheumatoid Factor) with Fcγ; V. Structural Aspects of Antibody Specificity; VI. Modeling Antibody-Combining Sites; VII. Structural Aspects of Catalytic Antibody Activity; References; Chapter 5. Antigen-Recognizing Molecules Other Than Antibodies; I. T-Cell Antigen Receptor; II. Proteins of Major Histocompatibility Complex. - II. Functional Aspects of Segmental FlexibilityReferences; Index; Color Plates Section. - III. Complexes of T-Cell Receptor and Peptide-MHCIV. CD1 Molecules; V. Natural Killer Cell Inhibitory Receptors; VI. Comparison of Antigen Binding by Various Antigen-Recognizing Molecules; References; Chapter 6. Interactions Outside the Antigen-Combining Site; I. Fc Receptor-Binding Sites; II. Complement-Binding Sites; III. Proteins Reacting with the Fc Portion; IV. Proteins Reacting with the Fab Portion; V. Lectins; VI. Molecular Chaperones; VII. Bacterial Immunoglobulin-Binding Proteins; References; Chapter 7. Segmental Movements of Immunoglobulin Molecules; I. General Aspects. - This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in
Emner
Sjanger
Dewey
ISBN
0125179707

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