Industrial Biotechnology : Sustainable Growth and Economic Success
Wim. Soetaert
Bok Engelsk 2010 · Electronic books.
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Utgitt | Hoboken : : Wiley, , 2010.
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Omfang | 1 online resource (523 p.)
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Opplysninger | Description based upon print version of record.. - Industrial Biotechnology: Sustainable Growth and Economic Success; Contents; Preface; List of Contributors; The Scope and Impact of Industrial Biotechnology; 1: History of Industrial Biotechnology; 1.1 Early History; 1.2 The Penicillin Story; 1.3 The Coming of the Cephalosporins; 1.4 The Waksman Era; 1.5 Strain Improvement; 1.6 Semi-Synthetic Antibiotics to Combat Resistant Microbes; 1.7 The Primary Metabolites; 1.7.1 Amino Acids; 1.7.2 Nucleotides; 1.7.3 Vitamins; 1.7.4 Organic Acids; 1.7.5 Alcohols; 1.7.6 Polymers. - 1.7.7 Specialty Sugars, Sugar Alcohols,L-Sugars, Oligosugars, Novel Extracellular Polysaccharides, Biopigments, Cosmetics Including Fragrants, and Microbial Enzymes for Chiral Synthesis and Other Applications1.8 The Shift from Antibiotics to Pharmacological Agents; 1.8.1 Enzyme Inhibitors; 1.8.2 Immunosuppressants; 1.8.3 Antitumor Agents; 1.8.4 Ergot Alkaloids; 1.8.5 Agricultural Compounds; 1.9 The Biopharmaceutical Revolution; 1.9.1 Human Insulin (Novolin, Humulin); 1.9.2 Erythropoietin (Epogen, Procrit); 1.9.3 Interferons; 1.9.4 Human Growth Hormone (Somatotropin, Somatropin. - 2.7.2 A Recently Launched and Rapidly Growing Industrial Biotechnology Product: 1,3-Propanediol2.7.3 An In-Development Industrial Biotechnology Product: Succinic Acid; 2.8 Conclusion and Future Perspectives; References; 3: Fermentation Technology; 3.1 Introduction; 3.2 Types of Fermentations; 3.3 Fermentation Process; 3.3.1 Inoculum Generation; 3.3.2 Growth and Product Formation; 3.4 Fermentation Medium Design; 3.5 Sterilization of Air and Fermentation Medium; 3.6 Environmental Factors; 3.7 Fermentation Kinetics; 3.7.1 Batch Fermentation; 3.7.2 Continuous Culture; 3.8 Fermentation Equipment. - 2: Industrial Systems Biology2.1 Introduction; 2.2 Industrial Biotechnology; 2.3 Market Drivers for Industrial Biotechnology; 2.4 Industrial Systems Biology; 2.5 Metabolic Models; 2.5.1 Microbial Metabolism-A Historical Perspective; 2.5.2 Genome Sequencing and Functional Genomics; 2.6 Reconstructed Metabolic Network Models; 2.6.1 Introduction; 2.6.2 Genome-Scale Reconstructed Network Process; 2.7 Industrial Systems Biology Case Studies; 2.7.1 A Mature and Developed Industrial Biotechnology Product: Bioethanol. - 3.8.1 Submerged Fermentation. - Humatrope, Nutropin, Protropin, Somatren, Serostim)1.9.5 Tissue Plasminogen Activator (Activase, Alteplase); 1.9.6 Interleukins; 1.9.7 Factor VIII; 1.9.8 Colony-Stimulating Factors; 1.9.9 Human DNase (Pulmozyme); 1.9.10 Glucocerebrosidas (Cerezyme); 1.9.11 Monoclonal Antibodies; 1.9.12 Additional Biopharmaceuticals; 1.10 Recombinant Hosts; 1.10.1 E. coli; 1.10.2 Yeasts; 1.10.3 Molds; 1.10.4 Insect Cells; 1.10.5 Mammalian Cells; 1.10.6 Transgenic Animals; 1.10.7 Transgenic Plants; 1.11 Enzymes; 1.12 Bioconversions; 1.13 Vaccines; 1.14 Systems Microbiology; References. - Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture.
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ISBN | 9783527314423
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