Comparison of pathological diagnostic criteria for Alzheimer disease
Z. Nagy
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 182- 189
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| Opplysninger | Because the clinical picture of Alzheimer disease (AD) is oftendifficult to discriminate from other dementing illnesses, thediagnosis of AD requires neuropathological confirmation. However, forthe pathological diagnosis of AD, there are no unanimously acceptedcriteria. The three currently used sets of pathological criteria(Khachaturian: Khachaturian, Arch Neural 1985;42:1097-105; Tierny:Tierney et al., Can J Neurol Sci 1986;13:424-6; CERAD: Mirra et al.,Neurology 1991;41:479-86) for the disease differ from each otherconsiderably. We applied these criteria to the first 43 consecutivesubjects (37 demented) with no neuropathology other than AD-typepathology from autopsies after longitudinal prospective clinicalstudy in the Oxford Project to Investigate Memory and Ageing(OPTIMA). The results show that the CERAD category of definite ADcorresponds closely with the cases that fulfill Tierney A3 inclusioncriteria for AD. The combined CERAD categories of possible, probable,and definite AD correspond closely to cases fulfilling Khachaturiancriteria for AD. The influence of a clinical diagnosis of dementiawhen Khachaturian and CERAD criteria were applied was considerablebecause between 93% and 90.7% of patients would have been categorizeddifferently depending on whether clinical dementia was present orabsent.
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| Emner |
