Age at onset and visuocognitive disturbances in Alzheimer disease


M. Fujimori
Bok Engelsk 1998
Utgitt
1998
Omfang
Side 163- 166
Opplysninger
We examined the relation of age at onset and visuocognitivedisturbances in Alzheimer disease (AD) using a large sample ofpatients, quantitative neuropsychological measures, and multivariatestatistics controlling for gender, education, stage of dementia, anddisease duration. Significant positive coefficients were obtainedwith forward and backward digit and visual spans, visual counting,copying Rey complex figure, and block design task. The resultsindicated that patients with early-onset AD performed worse than late-onset AD patients on these tasks. There was no significant effect ofage at onset on identification of overlapping figures, visual formdiscrimination, or Raven's colored progressive matrices. Thesefindings confirm the greater attentional and visuospatial impairmentsin early onset patients when these confounding factors werecontrolled for, although no significant effect of age at onset invisuoperceptual function was observed.
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