Bromocriptine treatment for perseveration in demented patients
T. Imamura
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 109- 113
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| Opplysninger | Some forms of behavioral perseveration may reflect the disruption ofspecific neurotransmitter systems including mesencephalicdopaminergic projection. We present an open-labeled trial of adopamine agonist for treating perseveration in dementia. Eightpatients with ischemic vascular or degenerative dementia completed a25-day trial of bromocriptine with a maximum daily dose of 10 mg.Patients were assessed with neuropsychological scales and a testbattery for detecting perseveration. Recurrent and stuck-in-set typesof perseveration significantly improved during the treatment, whereasmeasures for general attention and overall cognitive function showedno significant changes. We assume that bromocriptine supplemented themesolimbocortical or ventral mesostriatal dopamine system ameliorateda certain frontal lobe function such as focused attention or workingmemory and improved the patients' perseverations. Although this studyis preliminary because of the small sample size and open-labeleddesign, the results underline the possibility of pharmacotherapy forperseveration and recommend a double-blind, placebo-controlled study.
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| Emner |
