Clinical diagnosis of presenile Alzheimer's disease: A novel approach
Gerard McGonigal
Bok Engelsk
| Omfang | 6 s.
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| Utgave | Kopi
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| Opplysninger | Summary:A national retrospective survey of hospital records was used to select those patients with presenile dementia who had undergone neuropathological examination. The National Institurte of Neurological and Communicative Disorders and the Alzheimer's Desease and Related Disorders Association (NINCDS-ADRDA) clinical criteria for probable Alzheimer's disease and Hachinski scorewereapplied to each record before the neuropathological diagnosis was known. a discriminant analysis, which entered the criteria as variables, was performed. The diagnostic accuracy of the clinical criteria was compared before and after discriminant analysiis. One thousand sixhundred and seventy one records were scrutinised of which 61 patients had undergone neuropathological examination. NINCDS-ARDRA criteria had a diagnostic accuracy of 72%( specificity 88%, sensitivity 89%) compared to 77% (specificity 80%, sensitivity 75%) after analysis. NINCDS_ARDRA criteria together with the Hachinski score, presence of coexistent neurological disease and presence of coexistent systemic disease. The resulkts highlight limitations of current clinical criteria used to diagnose Alzheimer's disease and suggest that substantiail improvements are possible.
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