Regional hypometabolism related to language disturbance inAlzheimer's disease
N. Hirono
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 68- 73
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| Opplysninger | To elucidate the nature of language disturbance in Alzheimer'sdisease (AD) and the cerebral area involved in it, we studied 65 ADpatients with the Western Aphasia Battery (WAB) and with F-18-fluorodeoxyglucose and positron emission tomography. Partialcorrelations were evaluated between the Aphasia Quotient of WAB andregional cerebral glucose metabolism normalized by the mean metabolicrate in the bilateral primary sensorimotor areas after controllingage? sex, education and severity of illness. Language disturbance inAD is accounted for by deficits in the semantic processing oflanguage and is related to glucose hypometabolism in the inferiortemporal gyrus and inferior parietal lobule, especially in thedominant side. These results offer further evidence suggesting thatthe lexico-semantic processing system is mediated in these regions.
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| Emner |
