Excitatory pattern of gamma-interferon on natural killer cellactivity in senile dementia of the Alzheimer type
S.B. Solerte
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | Side 308- 313
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| Opplysninger | Spontaneous natural killer (NK) cell activity and NK-inducedcytotoxicity after interferon-gamma (IFN-gamma) were measured inhealthy elderly subjects and in patients with senile dementia ofAlzheimer type (SDAT) and multi-infarct dementia (MID). Normal basaland IFN-gamma-stimulated NK cytotoxicity were found in healthy oldsubjects and in patients with MID. On the contrary higher NKcytotoxicity after IFN-gamma (650 IU) was demonstrated in SDATpatients than in MID and healthy subjects (p < 0.001). A significantinverse correlation between the percent increase of NK cytotoxicityafter IFN-gamma and the Mini Mental State Examination score (p <0.001) was also demonstrated in patients with SDAT. Our data mightsuggest a cytokine-dependent mechanism of NK activation in SDATassociated with the neuroimmune hypothesis of the disease.
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| Emner |
