Low blood pressure and five-year mortality in a Stockholm cohort ofthe very old: Possible confounding by cognitive impairment and otherfactors
Z.C. Guo
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | Side 623- 628
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| Opplysninger | Objectives. Low blood pressure has often been reported to be relatedto excess mortality in people over the age of 75 years. This studyexamined whether other predictors may account for the association.Methods. A community-based cohort of 1810 people who were aged 75years and older was followed for 5 years.Results. The relative risk of death was 1.39 (95% confidence interval[CI] = 1.11, 1.73) for people with systolic pressure lower than 130mm Hg and 1.21 (95% CI = 1.02, 1.43) for those with diastolicpressure lower than 75 mm Hg, compared with corresponding referencegroups, when all other variables were simultaneously considered inCox proportional, hazards models. The observed association waspresent mainly in subjects with at least two of the three conditions(cardiovascular disease, limitation in activities of daily living, orcognitive impairment). The effect of low diastolic pressure onmortality was also significant in those with only cognitiveimpairment.Conclusions. Preexisting cardiovascular disease, limitation inactivities of daily living, and, more important, cognitive impairmentmay be responsible for the association of low blood pressure withincreased mortality in the very old in that they cause bothreductions in blood pressure and excess deaths.
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