Progressive formation of neuritic plaques and neurofibrillary tanglesis exponentially related to age and neuronal size - A morphometricstudy of three geographically distinct series of aging people
S.U. Dani
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | Side 217- 227
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| Opplysninger | Neuronal size and the incidence of neuritic plaques (NPs) andneurofibrillary tangles (NFTs) were morphometrically andquantitatively studied in the entorhinal cortex of 300 autopsiedindividuals without dementia in three geographically distinct series(Brazil, Germany and Japan), and an additional series including 30clinically diagnosed Alzheimer's disease patients. The mean ages atonset of NPs and NFTs were similar between the three normal series,and the incidence of NPs and NFTs increased exponentially with age,but at different rates. A correlation was found between largerneuronal size and higher incidence of NPs and NFTs. Neuronal sizedistribution largely seemed to account for the differences betweenthe series. While the onset of neurodegeneration may be tightlyprogrammed, i.e., in a species-specific manner, our data support theidea that the incidence of NPs and NFTs and the progression from NPsto NFTs may vary remarkably, depending on neuronal size.
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| Emner |
