Nicotinic agonist and antagonist effects on memory
E.D. Levin
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 188- 195
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| Opplysninger | Nicotine has been found by a variety of investigators to improvememory in rats, monkeys, and humans. Recent studies have helped todetermine the behavioral and pharmacological nature of criticalnicotine effects on memory function. Other nicotinic agonists,including ABT-418, GTS-21, or lobeline, can also significantlyimprove memory performance. Conversely, nicotinic antagonists, suchas mecamylamine, can impair memory. Nicotine can reverse memoryimpairments caused by aging or by lesions to hippocampal connections.The observation that nicotine improves memory performance when it isadministered by chronic infusion is potentially important for thedevelopment of treatments of cognitive impairment. Nicotinic agonistsshow promise for the development of novel treatments for cognitivedisorders. Some characteristics of nicotine, nicotinic receptors, andthe nature of the disorders to be treated, however, presentchallenges to the development of nicotinic-based treatments. (C) 1996Wiley-Liss, Inc.
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| Emner |
