The use of risperidone in severely demented patients with persistentvocalizations
L.C. Kopala
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | Side 73- 77
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| Opplysninger | Objective. The hypothesis being tested was that low doses ofrisperidone would diminish persistent, purposeless vocalizations intwo severely demented geriatric women. A secondary hypothesis wasthat the severe tardive dyskinesia observed in one patient wouldimprove after risperidone treatment.Design. An intrasubject on-off-on design was employed.Setting. A chronic care facility in Canada.Subjects. Two inpatients with DSM-IV (American PsychiatricAssociation) diagnosis of combined Alzheimer-vascular dementia.Measures. Nursing assessment of frequency of vocalizations,Extrapyramidal System Rating Scale (ESRS) and Folstein Mini MentalState Examination (MMSE).Results. With risperidone treatment, the vocalizations diminished toless than 20% of baseline ratings. For the patient with dyskinesia,ESRS dyskinetic movement scores decreased (baseline = 27; afterrisperidone 8 weeks = 16). No change was observed for the MMSE.Conclusions. The findings support the main hypothesis. The secondaryhypothesis was also supported. Further studies of larger numbers ofsubjects are required to substantiate these preliminary findings.
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