Cognitive effects of scopolamine in dementia
J.M. Rabey
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 873- 881
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| Opplysninger | Cholinergic deficiency was postulated to play an important role inthe mental decline observed in Alzheimer's (AD), Parkinson's (PD) andmultiinfarct (MID) dementia. In the present study, 11 AD, 8 MID and 7FD patients (DSM III-R diagnostic criteria for dementia) and 9healthy age-matched controls (CTRL) were given IV 0.5 mg scopolamine(SCO) or placebo (PLA) in random order (double blind) within oneweek. The Hebrew Short Mental Test (SMT) and Wechsler Memory Scale(WMS) were administered before and after SCO and PLA in each patient.A comparison of SCO vs. PLA utilizing MANCOVA (the covariate beingthe basal mental performance [BAS] with SMT or WMS) showed that SCOaffected all the groups similarly, except for the Wechsler subtest oflogic memory which showed larger deterioration in CTRL compared todemented patients. ANOVA and MANCOVA analyses did not distinguishbetween the three demented groups. SCO administration does notdifferentiate between demented patients and CTRL and does not enablediscrimination between patients with AD, MID and PD. Moreover, someCTRL with still normal cognitive performance, but lower BAS may bemore vulnerable to SCO than others. The integrity of the cholinergicsystem may be responsible for the different sensitivity to SCOchallenge.
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| Emner |
