Neuropsychological features of early Alzheimer's disease: Preclinical and clinical stages
Ove Almkvist
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 63- 71
|
| Opplysninger | In the preclinical stage of Alzheimer's disease (AD), studies ofasymptomatic mutation carriers have identified impairments inepisodic memory. Other cognitive functions show no or slightimpairment suggesting that preclinical AD is a unifunctionalcognitive syndrome; the brain is affected selectively andpredominantly in the medial temporal structures. In the earlyclinical stage, deficits occur in episodic memory, verbal abilities,visuo-spatial functions, attention, and executive functions. ADbecomes a multifunctional cognitive syndrome and the brain'sassociation cortices are affected. Nevertheless, sensory-motorperformance and procedural memory seem to be intact and only slightimpairment may be seen in primary memory. In advanced AD, cognitivedysfunction including deficits is global in primary memory, althoughsensory-motor performance may be well preserved. The brain'sassociation cortices are severely affected. The sequence of cognitivedecline, from unifunctional to global deficits, conforms to the three-stage development of neurofibrillary tangles described by Braak andBraak.
|
| Emner |
