The prediction of Alzheimer disease: The role of patient andinformant perceptions of cognitive deficits
M.C. Tierney
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 423- 427
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| Opplysninger | Objective: To determine whether the perceptions of patients'cognitive deficits by either the patient or an informant couldpredict who would develop Alzheimer disease (AD) in a group of 120memory-impaired patients without dementia.Methods: At entry into the study, patients were assessed by severalmeasures that included neuropsychological tests and the CambridgeMental Disorders of the Elderly Examination Interview Schedule. Thelatter schedule asks patients and their informants about theirperceptions of cognitive deficits in the patients. After 2 years,patients underwent a diagnostic workup for AD: 29 had developedprobable AD, whereas the other 91 did not develop dementia. We usedlogistic regression analyses to examine the predictive accuracy ofpatients' and informants' perceptions of deficits at entry into thestudy.Results: Informants' perceptions, not patients' perceptions,contributed significantly to the prediction of AD. The bestprediction of AD was obtained by the regression model that includedboth informants' perceptions and 2 neuropsychological tests.Conclusions: These results demonstrate the clinical use of includinginformant perceptions about patients' cognitive deficits in thediagnostic assessment of AD. They also indicate that patients'perceptions of their own deficits are not predictive of AD, but arerelated to depressive affect.
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