Enhanced cytotoxic response of natural killer cells to interleukin-2in Alzheimer's disease
S.B. Solerte
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 343- 348
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| Opplysninger | Experimental data suggest an involvement of immune cellularcomponents in the development of Alzheimer's disease (AD). Againstthis background, the spontaneous natural killer (NK) cell activityand the NK-induced cytotoxicity after interleukin-2 (IL-2) werestudied in healthy elderly subjects and in patients with dementia ofAlzheimer type (SDAT) and multi-infarct type (MID). Higher NKcytotoxicity (expressed as total lysis and percent increase) atdifferent IL-2 concentrations (50 and 100 IU/ml/cells) wasdemonstrated in patients with SDAT than in healthy elderly subjects(p < 0.001) and MID patients (p < 0.001). NK cell activity of MIDpatients was similar to that of healthy elderly and healthy youngsubjects. A negative correlation between the percent increase in NKcytotoxicity after IL-2 and the Mini Mental State Examination Scorewas also found in SDAT patients (p < 0.01). Alterations of IL2-mediated NK cytotoxicity may therefore support the neuroimmunehypothesis of AD.
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| Emner |
