The behavior pathology in Alzheimer's disease rating scale (BEHAVE-AD): Reliability and analysis of symptom category scores
S.G. Sclan
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 819- 830
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| Opplysninger | The interrater reliability of the Behavior Pathology in Alzheimer'sDisease Rating Scale (BEHAVE-AD), a psychiatric rating scaleespecially designed for the evaluation of behavioral disturbances indementia patients, was studied in both English-speaking US patientsand a French-speaking elderly patient population from France.Additionally, the quantitative relationship between severity ofAlzheimer's disease (AD) and mean scores on each of the BEHAVE-ADcategories and mean total BEHAVE-AD score was determined in aseparate study of 140 patients diagnosed as having probable AD. Inboth reliability studies significant correlations were obtained forall BEHAVE-AD symptom category scores and for mean total BEHAVE-ADscores. Analysis of BEHAVE-AD scores as a function of diseaseseverity demonstrated a non-linear relationship between severity ofbehavioral symptoms and the global and cognitive advance of AD.Moreover, score analysis of the BEHAVE-AD indicates that thesebehavioral disturbances become most severe in the moderate andmoderately severe stages of the illness. The results of these studiesprovide support for the reliability of the BEHAVE-AD. Additionally,the BEHAVE-AD provides basic knowledge about the nature and severityof the behavioral symptoms in AD. The latter information may beuseful for the development of appropriate and effectivepsychopharmacologic intervention strategies for these difficult tomanage behaviors. Furthermore, these results have implications forthe methodology of pharmacologic trials of putative cognitive-enhancer compounds in AD.
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