Variables associated with cognitive function in elderly CaliforniaSeventh-day Adventists
G.E. Fraser
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 1181- 1190
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| Opplysninger | From a cohort of white, non-Hispanic California Seventh-dayAdventists, 99 subjects over age 75 years in 1991 were randomlyselected. Dietary habits and educational status had been measured in1976. Subjects completed the Mini-Mental State Examination (MMSE) in1991, and at that time, they or caregivers also gave information oncurrent medical problems and drug therapy. Those who ate morecalories in 1976 had lower MMSE scores in 1991 (p = 0.03), anassociation strengthened by excluding those with previous stroke orParkinson's disease by 1991. This raises the possibility that higherconsumption of calories in middle age may accelerate the decline incognitive function seen with aging, as apparently occurs in someanimals. Less-educated subjects had lower MMSE scores, especiallyamong the very elderly. The statistical model predicts that thenegative association between use of psychotropic drugs and MMSE score(p = 0.004) is particularly potent in those cognitively impaired forother reasons. If causal, this suggests that physicians should usethese agents very cautiously in such subjects.
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| Emner |
