Physical aggression is associated with preservation of substantianigra pars compacta in Alzheimer disease
J. Victoroff
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 428- 434
|
| Opplysninger | Objective: To investigate specific neuropathologic correlates ofagitation and physical aggression in Alzheimer disease (AD).Design: Neuronal counts in the nucleus basalis, locus ceruleus, andsubstantia nigra were compared in the brains of patients withpathologically definite AD with or without histories of agitation orinterpersonal violence.Setting: Alzheimer disease center of a university department ofneurology.Main Outcome Measures: Neuron densities in the nucleus basalis andabsolute neuron counts in the locus ceruleus and substantia nigrapars compacta.Results: The patients with AD who had histories of unequivocalinterpersonal violence had significantly greater neuron counts in thesubstantia nigra pars compacta than did the nonviolent patients withAD. This finding remained significant after multiple clinical andneuropathologic variables were adjusted for. Neuropathologic findingsin the nucleus basalis and locus ceruleus were not different betweenviolent and nonviolent patients.Conclusion: Preservation of pigmented substantia nigra neurons may bea risk factor for physical aggression in AD.
|
| Emner |
