Increase in single L-type calcium channels in hippocampal neuronsduring aging
O. Thibault
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 1017- 1020
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| Opplysninger | Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1hippocampal neurons during aging. However, the molecular basis forthis elevation is not known. The partially dissociated hippocampal(''zipper'') slice preparation was used to analyze single Ca2+channel activity in CA1 neurons of adult and aged rats. Total L-typeCa2+ channel activity in patches was found to increase with aging,primarily because of an increase in the density of functionalchannels. Learning in aged animals was inversely correlated withchannel density, This increase in functional Ca2+ channels with agingcould underlie the vulnerability of neurons to age-associatedneurodegenerative conditions.
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| Emner |
