Apolipoprotein E genotype in the prediction of cognitive decline anddementia in a prospectively studied elderly population
C. Brayne
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 169- 174
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| Opplysninger | An increased apolipoprotein E (ApoE) type epsilon 4 allele frequencyis associated with both sporadic and familial late-onset Alzheimer'sdisease (AD). The age of onset of disease in patients homozygeus forthe epsilon 4 allele appears to be decreased by approximately 15years compared with E2/3 individuals. In order to assess theinfluence of this allele on both dementia and cognitive decline inthe elderly we have determined the ApeE genotype of 150 individualsover the age of 75 years who have taken part in a longitudinal study.Homozygosity for the epsilon 4 allele was rare, Of the 2 homozygotes,1 was severely demented but the other did not receive a clinicaldiagnosis of dementia. The latter individual did demonstrate markedcognitive decline over a 28-month period. There was a consistentassociation between the presence of an epsilon 4 allele and both theclinical diagnosis of dementia and cognitive decline. These findingsconfirm a genetic heterogeneity in late-onset sporadic AD and promptcaution in the use of ApoE genotype to predict an elderlyindividual's susceptibility to either dementia or cognitive decline.
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| Emner |
