Hippocampal pathology reflects memory deficit and brain imagingmeasurements in Alzheimer's disease: Clinicopathologic correlationsusing three sets of pathologic diagnostic criteria
Z. Nagy
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 76- 81
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| Opplysninger | Neurofibrillary tangles (NFT), neuritic plaques and amyloid load werequantified in sections of the hippocampus at the level of the lateralgeniculate body in 41 consecutive cases fulfilling pathologicalcriteria for diagnosis of Alzheimer's disease (AD) and coming toautopsy after longitudinal study during life. A strong correlationwas found between NFT density in the hippocampus and cognitiveimpairment scores obtained shortly before death, particularly withscores of memory impairment. Weaker and less consistent correlationswere found for hippocampal neuritic plaques and amyloid load withcognitive/memory deficits. No significant correlations were foundbetween hippocampal pathology and either age of onset or diseaseduration. All three measures of hippocampal pathology were inverselycorrelated with the minimum medial temporal lobe (MTL) width, ameasure of the MTL atrophy made from temporal-lobe-oriented X-raycomputed tomography scans performed during life; the strongestcorrelation being between atrophy of the MTL and NFT density in thehippocampus.
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| Emner |
