Pattern visual evoked potential mapping in Alzheimer's disease:Correlations with visuospatial impairment
V. Martinelli
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 63- 68
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| Opplysninger | We evaluated pattern visual evoked potentials (PVEPs) in patientswith Alzheimer's disease (AD) and correlated the neurophysiologicalresults with visuospatial performances in order to understand betterthe underlying causes of visual disturbances. Latencies andtopographical distribution of PVEP components were evaluated in 20 ADpatients who underwent an extensive battery of neuropsychologicaltests. Mean latencies of N70 and P100 were normal in AD patients,while mean latencies of N140 and P200 were significantly increased incomparison with age-matched healthy controls. The topographicaldistribution of PVEP components did not show any significantdifference between the two groups. Visuospatial impairment wasdetected in 8 patients (40%). Statistically significant positivecorrelations were observed between P200 amplitude (posterior righthemisphere mean z score) and performance in visuospatial tests. Ourdata are consistent with a sparing of foveal retinocortical pathwaysand with the selective dysfunction of either corticocorticalconnections between the striate cortex and the visual associativestructures or of right temporo-parieto-occipital visual analyzers.
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| Emner |
