Specificity of temporal amygdala atrophy in Alzheimer's disease:Quantitative assessment with magnetic resonance imaging
C. Maunoury
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 10- 14
|
| Opplysninger | The aim of the study was to assess the specificity of temporalamygdala (TA) atrophy with magnetic resonance imaging (MRI) bycomparing a group of early impaired patients with Alzheimer's disease(AD) with 'other types of dementia' and controls. In this prospectivecase-control study, 41 patients were selected: 12 with probable ADaccording to NINCDS-ADRDA and CERAD inclusion and exclusion criteria,14 with other types of dementia and 15 age-matched control subjects,Two radiologists blindly measured the TA volumes on coronal obliquecontiguous slices with a 1.5-tesla MRI scanner. TA volumemeasurements obtained by the 2 observers and right-left TA valueswere not significantly different. A significant TA atrophy was foundin the AD group as compared to the other groups, with 39.7% (p <0.001) difference in TA volumes between AD and other types ofdementia groups and 41.4% (p < 0.0005) difference between AD andcontrol groups. There was no significant difference between othertypes of dementia and control groups. There was an overlap betweenthe three groups for 4 patients. TA atrophy assessed with MRI couldbe of diagnostic value in AD, especially in the early stage of thedisease.
|
| Emner |
