Aluminium and Alzheimer's disease: Review of possible pathogenicmechanisms
R.A. Armstrong
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 1- 9
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| Opplysninger | Chronic exposure to aluminium (Al) remains a controversial possiblecause of sporadic forms of Alzheimer's disease (AD). This articlereviews the evidence that once Al enters the brain and individualbrain cells, it may be involved in three pathological processes: (1)the production of abnormal forms of tau leading to the formation ofcellular neurofibrillary tangles and neuropil threads; (2) theprocessing of the amyloid precursor protein, resulting in theformation of beta-amyloid deposits and senile plaques, and (3) thatvia the mutual histocompatibility system, Al could be involved in theinitiation of the immune response observed in AD patients. Despiterecent evidence that Al could be involved in these processes, aconclusive case that exposure to Al initiates the primarypathological process in sporadic AD remains to be established.
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| Emner |
