Rate of progression of alzheimer's disease is associated with genetic risk
L.A. Farrer
Bok Engelsk
| Utgitt | LA Farrer Boston Univ Sch Med Dept Neurol
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| Opplysninger | Objective: To determine whether differences in genetic origin affect the clinical course of Alzheimer's disease (AD). The limited number of cases of AD linked to a known genetic abnormality is a major obstacle in determining whether the disorder is expressed differently in patients with familial AD and those with sporadic AD. Design: Cross-sectional study. Setting: Memory Disorders Unit of the Alzheimer's Disease Research Center at Massachusetts General Hospital, Boston. Participants: A total of 186 patients who had a clinical diagnosis of probable AD, family history information available for all first-degree relatives, and three or more outpatient visits were identified from a consecutive case series. Main Outcome Measure: Rate of decline on the Blessed Dementia Scale and the Activities of Daily Living Scale. Results: We calculated the probability that an individual patient has a major genetic locus for AD (MGAD) using an algorithm that incorporates information from a genetic model and the individual's family. We measured cognitive and functional changes by the average annual rate of increase (slope) in scores for the Blessed Dementia Scale and Activities olacke, L.
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