MRI-based measurement of hippocampal volume in patients with combat-related posttreumatic stress disorder
J. Douglas et al. Bremner
Bok Engelsk
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| Utgave | Kopi
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| Opplysninger | CONCLUSIONS: These findings are consistent with a smaller right hippocampal volume in PTSD that ins associated with functional deficits in verbal memory.. - METHOD: Magnetic resonance imaging was used to measure the volume of the hippocampus in 26 Vietnam combat veterans with PTSD and 22 comparison subjects selected to be similar to the patients in age, sex, race, years of education, socioeconomic status, body size and years of alcohol abuse.. - OBJECTIVE:Studies in non-human primates suggest that high levels of cortisol associated with stress have neurotoxic effects on the hippocampus, a brain structure involved in memory.The authors previously showed that patients with combat-related posttreumatic stress disorder (PTSD) had defgicits in short-term memory. The purpose of this study was to compare the hippocampus in pocampal volume of patients with PTSD to that of subjects without psychiatric disorder.. - RESULTS: The PTSD patients had a statistically significant 8% smaller right hippocampal volume relative to that of the comarison subjects, but there was no difference in the volume of othe brain regions (caudate and temporal lobe). Deficits in short-term verbal memory as measured with the Wechsler Memory Scale were associated with smaller right hippocampal volume in the PTSD patients only.
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