Repeated exposure to the Mini-Mental State Examination and the Information-Memory-Concentration Test results in a practice effect in Alzheimer's disease
D. et al. Galasko
Bok Engelsk 1993
| Utgitt | 1993
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| Omfang | 5 s.
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| Utgave | Særtrykk/ Kopi
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| Opplysninger | Abstract We analyzed short-term variation of Mini-Mental State Examination (MMSE) and Information Memory-Consentration (IMC) Test scores in 39 patients with Alzheimer's disease(AD), tested four times over 6 weeks. Although analysis of variance had failed to show a significant "learning" effect or other trends, we reexamined the data using repeated measures models, with and without a learning effect. In the n\model without a learning effect, mean MMSE scores decreased minimally and mean IMC scores decreased by 0.84 points over 6 weeks. In the model that allowed a potential learning effect between the first and second test sessions, scores increased significantly, by 1.12 +- 0.47 points for the MMSE and 1.04 +- 0.43 points for the IMC test. Patients' test scores predicted from the models had less variability than did their raw scores. The short-term practice effect, although small, should be considered in interpreting changes in scores, especially in therapeutic studies in AD.
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