Alzheimer's disease - a spirochetosis?
Judit Miklossy
Bok Engelsk
| Omfang | 8 s. : ill.
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| Utgave | Særtrykk/Kopi
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| Opplysninger | Abstract The aetiology of Alzheimer's disease (AD) which affects a large proportion of the aged population in unknown and the treatment unresolved. The role of beta amyloid protein (BA4), derived from a larger amyloid precursor protein (APP) in AD is the subject of intense research. Here I report obervations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue. Thirteen age-matched control cases were without spirochetes. Reference strains of spirochetes and those isolated from brains of AD patients showed positive immunoreaction with monoclonal antibody against the B amyloid precursor protein. These observations suggest that spirochetes may be one of the causes of AD and that they may be the source of the B amyloid deposited in the AD brain.
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