Phenotypic Variation : Exploration and Functional Genomics
Moyra. Smith
Bok Engelsk 2011 · Electronic books.
| Utgitt | New York ; Oxford : : Oxford University Press, , 2011.
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| Omfang | 1 online resource (253 p.)
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| Opplysninger | Description based upon print version of record.. - Cover; Contents; 1. Phenotype and Functional Genomics: Introduction; 2. Evolution; 3. Genomic Architecture and Copy Number Changes; 4. Linkage, Association, and Linkage Disequilibrium; 5. Regulation of Transcription, Splicing and Translation: Impact of Perturbation on Phenotype; 6. Mitochondria: Genome, Functions, and Phenotype; 7. Quality Surveillance; 8. Neurodevelopment and Functional Genomics; 9. Neurobehavioral Disorders; 10. Molecular Analyses of Malformation Syndromes; 11. Multiple Pathways including Environmental Factors that Lead to a Specific Phenotype with Later Onset; 12. Epilogue. - ReferencesIndex. - During the past two decades international collaborative studies have yielded extensive information on genome sequences, genome architecture and their variations. The challenge we now face is to understand how these variations impact structure and function of organelles, physiological systems and phenotype. The goal of this book is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. In this book the author reviews published research in functional genomics carried out primarily since 2006 that sheds light on
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| Emner | Biological Science Disciplines
Computational Biology Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Vis mer... Disciplines and Occupations
Diseases Genetic Phenomena Genomics Natural Science Disciplines Nervous System Diseases Phenomena and Processes Congenital Abnormalities -- Genetics. Genetic Variation. Nervous System Diseases -- Genetics. Phenotype. Phenotypic plasticity. Biology Genetics Health & Biological Sciences gentikk abnormiteter nervesystem sykdommer phenotype fremtoningspreg observerbare egenskaper arveanlegg miljø |
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| ISBN | 9780195379631
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