Nutritional Genomics : Discovering the Path to Personalized Nutrition
Jim. Kaput
Bok Engelsk 2006 · Electronic books.
| Annen tittel | |
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| Utgitt | Hoboken : : Wiley, , 2006.
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| Omfang | 1 online resource (506 p.)
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| Opplysninger | Description based upon print version of record.. - NUTRITIONAL GENOMICS; CONTENTS; Contributors; Foreword; Preface; Acknowledgments; 1 AN INTRODUCTION AND OVERVIEW OF NUTRITIONAL GENOMICS: APPLICATION TO TYPE 2 DIABETES AND INTERNATIONAL NUTRIGENOMICS; 1.1 Introduction; 1.2 Understanding T2DM: The Current View of T2DM and Treatment Options; 1.3 Understanding T2DM: Begin Before Conception; 1.4 Understanding T2DM: Genetic Complexity; 1.5 Understanding T2DM: QTLs in Humans; 1.6 Understanding T2DM: From Birth Onward; 1.7 Understanding T2DM: Metabolomics; 1.8 Understanding T2DM: Environmental Influences. - 1.9 Understanding T2DM: Environment Is More Than Diet1.10 Understanding T2DM: Data Acquisition and Analyses; 1.11 Bioinformatics and Biocomputation; 1.12 Converting Science into Practice; 1.13 Research Ethics and Genetic Privacy; 1.14 Health Disparities; 1.15 Public and International Policies; 1.16 Conclusion; Acknowledgment; References; 2 THE PURSUIT OF OPTIMAL DIETS: A PROGRESS REPORT; 2.1 Introduction; 2.2 Considerations in Defining an Optimal Diet; 2.3 Dietary Fat and Specific Fatty Acids; 2.4 Carbohydrates; 2.5 Protein; 2.6 Vegetables and Fruits; 2.7 Calcium and Dairy Products. - 2.8 Salt and Processed Meats2.9 Alcohol; 2.10 Vitamin and Mineral Supplements; 2.11 Potential Impact of Optimal Diet and Life-Style Changes; 2.12 Conclusion; Acknowledgment; References; 3 GENE-ENVIRONMENT INTERACTIONS: DEFINING THE PLAYFIELD; 3.1 Introduction; 3.2 Genetic Variability; 3.3 How to Detect Genetic Variability; 3.4 What to Analyze; 3.5 Environmental Factors; 3.6 Gene-Environment Interactions: Focus on Diet; 3.7 Common Genetic Variants and Gene-Diet Interactions Modulating Plasma Lipoprotein Concentrations; 3.8 Gene-Microorganisms Interactions; 3.9 The Microbiome (Microbiota). - 3.10 ConclusionAcknowledgments; References; 4 METABOLOMICS: BRINGING NUTRIGENOMICS TO PRACTICE IN INDIVIDUALIZED HEALTH ASSESSMENT; 4.1 Introduction; 4.2 Opportunities for Foods and Health; 4.3 Nutrigenomics; 4.4 Metabolomics; 4.5 Genomics; 4.6 Metabolome Assembly and Annotation; 4.7 Bioinformatics: Knowledge Management from Genomics and Metabolomics to Health Assessment; 4.8 Conclusion; References; 5 GENETIC AND MOLECULAR BUFFERING OF PHENOTYPES; 5.1 Introduction; 5.2 Examples of Buffering; 5.3 Experimental Concepts for Genetic Buffering Analysis. - 5.4 Experimental Platforms for Global Genetic Interaction Analysis5.5 Conclusion; Acknowledgments; References; 6 GENE-GENE EPISTASIS AND GENE-ENVIRONMENT INTERACTIONS INFLUENCE DIABETES AND OBESITY; 6.1 Gene-Gene and Gene-Environment Interactions; 6.2 Epistasis and Gene-Environment Interactions in Obesity and Diabetes; 6.3 Animal Models for Detecting Gene Interactions; 6.4 Gene-Gene Interaction in Obesity and Diabetes; 6.5 Dietary Fat in Obesity and Diabetes; 6.6 Maternal Effects; 6.7 Future Directions and Conclusion; References; 7 NUTRIENTS AND GENE EXPRESSION; 7.1 Introduction. - 7.2 SREBPs and ChREBP: Transcription Factors Influenced by Dietary Lipids and Glucose. - The definitive guide to the basic principles and latest advances in Nutritional GenomicsThough still in its infancy, nutritional genomics, or ""nutrigenomics,"" has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling ""personalized"" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or pos
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| ISBN | 0471683191. - 9780471683193
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