Platelet Protocols : Research and Clinical Laboratory Procedures


Melanie McCabe. White
Bok Engelsk 1999 · Electronic books.
Utgitt
Burlington : : Elsevier Science, , 1999.
Omfang
1 online resource (131 p.)
Opplysninger
Description based upon print version of record.. - Front Cover; Platelet Peotocols: Research and Clinical Laboratory Procedures; Copyright Page; Contents; Preface; Acknowledgments; Chapter One. Basic Introduction to Platelets; Introduction; Platelets in Hemostasis; Membrane Surface Proteins; Events Associated with Platelet Aggregation; Platelet Agonists; Coagulation; Chapter Two. Laboratory Evaluation of Platelet Function; Introduction; Variables; Drawing and Processing Blood for Platelet Aggregation; Platelet Aggregation and Secretion; Platelet Agonists; Clot Retraction; Platelet Adhesion. - Cytoskeleton Preparations from Washed PlateletsPreparing Gel-Filtered Platelets; Preparing Washed Platelets; SDS Gel Electrophoresis; Gel Recipes; Western Blots (of Acrylamide Gels); Staining of Platelets for Flow Cytometric Analysis; Sources of Aggregometers and Aggregation Reagents; Index; Color Plate Section. - Flow Cytometric Analysis of Platelet Surface ProteinsReceptor Occupancy; Chapter Three. Functional Abnormalities of Platelets; Introduction; Storage Pool Disorders (SPDs) and Release Defects; Chapter Four. Therapeutic Approaches to Inhibition of Platelet Function; Introduction; GPIIL-IIIa Antagonists; Other Anti-Platelet Therapies; Drugs that May Affect Platelet Function; Clinical Trials and Pharmacodynamic Measurementsof Platelet Inhibition; Appendix; Recipes for Citrate-Based Anticoagulants; Inhibitors Used in Platelet Techniques; Cytoskeletal Preparation from PRP. - Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and cl
Emner
Blood platelet disorders
Blood platelets
Blood platelets - Aggregation
Analytical, Diagnostic and Therapeutic Techniques and Equipment
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Dewey
ISBN
0123842603

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